:root {
  --bg: #edf1f3;
  --bg-deep: #dce4e8;
  --surface: rgba(255, 255, 255, 0.76);
  --surface-strong: #ffffff;
  --ink: #10212c;
  --muted: #54646f;
  --line: rgba(16, 33, 44, 0.12);
  --accent: #663038;
  --accent-soft: #a97880;
  --accent-gold: #b69352;
  --accent-blue: #557d92;
  --accent-rose: #b88274;
  --navy: #173243;
  --teal: #315867;
  --fog: #f7f9fa;
  --shadow: 0 14px 34px rgba(12, 25, 33, 0.08);
  --radius-xl: 18px;
  --radius-lg: 14px;
  --radius-md: 10px;
  --max-width: 1180px;
}

* {
  box-sizing: border-box;
}

html {
  scroll-behavior: smooth;
  scroll-padding-top: 6rem;
}

body {
  margin: 0;
  font-family: "Manrope", sans-serif;
  color: var(--ink);
  background:
    radial-gradient(circle at top left, rgba(85, 125, 146, 0.11), transparent 30%),
    radial-gradient(circle at 82% 12%, rgba(102, 48, 56, 0.13), transparent 20%),
    radial-gradient(circle at 18% 78%, rgba(184, 130, 116, 0.12), transparent 24%),
    linear-gradient(180deg, #f8fafb 0%, var(--bg) 46%, var(--bg-deep) 100%);
}

body::before {
  content: "";
  position: fixed;
  inset: 0;
  pointer-events: none;
  background-image: linear-gradient(rgba(16, 33, 44, 0.025) 1px, transparent 1px),
    linear-gradient(90deg, rgba(16, 33, 44, 0.025) 1px, transparent 1px);
  background-size: 36px 36px;
  mask-image: linear-gradient(180deg, rgba(0, 0, 0, 0.35), transparent 85%);
}

img,
video {
  display: block;
  max-width: 100%;
}

a {
  color: inherit;
  text-decoration: none;
}

.site-shell {
  min-height: 100vh;
}

.hero,
.section {
  width: min(calc(100% - 2rem), var(--max-width));
  margin: 0 auto;
}

.hero {
  padding: 1.2rem 0 1.4rem;
}

.topbar {
  position: fixed;
  top: 0;
  left: 50%;
  transform: translateX(-50%);
  width: 100%;
  z-index: 20;
  display: flex;
  align-items: center;
  justify-content: space-between;
  gap: 1rem;
  padding: 1rem max(1rem, calc((100% - var(--max-width)) / 2));
  margin-top: 0;
  background:
    linear-gradient(135deg, rgba(251, 248, 248, 0.98), rgba(245, 239, 240, 0.98)),
    #f8fafb;
  border: 0;
  border-bottom: 1px solid rgba(16, 33, 44, 0.08);
  backdrop-filter: none;
  border-radius: 0;
  box-shadow:
    0 12px 28px rgba(16, 33, 44, 0.08),
    0 2px 6px rgba(16, 33, 44, 0.04);
}

.brand {
  display: inline-flex;
  align-items: center;
  gap: 0.85rem;
  min-width: 0;
}

.brand strong,
.brand em {
  display: block;
}

.brand strong {
  font-size: 1rem;
}

.brand em {
  font-style: normal;
  font-size: 0.82rem;
  color: var(--muted);
}

.brand-mark {
  display: grid;
  place-items: center;
  width: 2.7rem;
  height: 2.7rem;
  border-radius: 0.85rem;
  background:
    radial-gradient(circle at 50% 50%, rgba(255, 255, 255, 0.9), transparent 18%),
    linear-gradient(145deg, rgba(102, 48, 56, 0.94), rgba(74, 31, 39, 0.9));
  box-shadow: inset 0 0 0 1px rgba(255, 255, 255, 0.35);
}

.brand-mark svg {
  width: 1.95rem;
  height: 1.95rem;
  fill: none;
  stroke: rgba(255, 255, 255, 0.92);
  stroke-linecap: round;
  stroke-linejoin: round;
  stroke-width: 2.4;
}

.brand-mark svg circle {
  fill: rgba(255, 255, 255, 0.92);
  stroke: none;
}

.nav-links {
  display: flex;
  align-items: center;
  gap: 1rem;
}

.nav-links a {
  font-size: 0.95rem;
  color: var(--muted);
}

.nav-links a:hover,
.nav-links a:focus-visible {
  color: var(--ink);
}

.menu-toggle {
  display: none;
  border: 0;
  background: var(--accent);
  color: white;
  border-radius: var(--radius-md);
  padding: 0.8rem 1rem;
  font: inherit;
}

.hero-grid {
  display: grid;
  grid-template-columns: 1.32fr 0.9fr;
  gap: 1.5rem;
  align-items: stretch;
  padding-top: 6.5rem;
}

.hero-copy,
.hero-panel,
.card,
.portrait-card,
.people-column,
.finding-card {
  background:
    linear-gradient(180deg, rgba(255, 255, 255, 0.84), rgba(251, 248, 248, 0.72)),
    var(--surface);
  border: 1px solid rgba(255, 255, 255, 0.7);
  border-radius: var(--radius-xl);
  box-shadow: var(--shadow);
  backdrop-filter: blur(16px);
}

.hero-copy,
.hero-panel,
.card,
.portrait-card,
.people-column,
.finding-card {
  animation: fade-up 0.7s ease both;
}

.hero-copy {
  padding: 2.15rem;
  position: relative;
  overflow: hidden;
}

.hero-copy::before {
  content: "";
  position: absolute;
  inset: 0;
  background:
    radial-gradient(circle at 80% 18%, rgba(102, 48, 56, 0.16), transparent 18%),
    radial-gradient(circle at 10% 90%, rgba(85, 125, 146, 0.15), transparent 22%),
    radial-gradient(circle at 45% 70%, rgba(182, 147, 82, 0.08), transparent 20%);
  pointer-events: none;
}

.hero-copy > * {
  position: relative;
}

.eyebrow,
.panel-kicker,
.finding-label,
.topic-tag {
  letter-spacing: 0.18em;
  text-transform: uppercase;
  font-size: 0.74rem;
  color: var(--accent);
}

h1,
h2,
h3,
h4 {
  margin: 0;
  font-family: "Source Serif 4", serif;
  line-height: 1.04;
}

h2 {
  font-size: clamp(2rem, 3.2vw, 3.15rem);
}

h3 {
  font-size: 1.4rem;
}

.hero-intro,
.lead,
.pi-titles,
.section-heading p,
.card p,
.finding-card p,
.member-card p,
.member-card span,
.alumni-card p,
.alumni-card span,
.portrait-caption,
.hero-panel p {
  color: var(--muted);
  line-height: 1.72;
}

.hero-title {
  margin: 0 0 0.45rem;
  max-width: 42rem;
  font-family: "Source Serif 4", serif;
  font-size: clamp(1.35rem, 2.15vw, 1.9rem);
  line-height: 1.14;
  letter-spacing: -0.015em;
  color: var(--ink);
}

.hero-intro {
  margin: 0;
  max-width: 40rem;
  font-size: 1.06rem;
}

.hero-video-placeholder {
  display: grid;
  gap: 0.55rem;
  min-height: 12.2rem;
  margin: 0.85rem 0 1rem;
  padding: 0.8rem;
  border-radius: calc(var(--radius-xl) - 8px);
  background:
    radial-gradient(circle at 28% 36%, rgba(169, 120, 128, 0.34), transparent 11%),
    radial-gradient(circle at 63% 48%, rgba(85, 125, 146, 0.24), transparent 15%),
    radial-gradient(circle at 42% 68%, rgba(182, 147, 82, 0.16), transparent 12%),
    linear-gradient(145deg, rgba(16, 33, 44, 0.92), rgba(74, 31, 39, 0.88));
  border: 1px solid rgba(255, 255, 255, 0.24);
  color: white;
  box-shadow: inset 0 0 0 1px rgba(255, 255, 255, 0.08);
}

.hero-video {
  width: min(100%, 26.5rem);
  aspect-ratio: 426 / 240;
  display: block;
  justify-self: center;
  border-radius: calc(var(--radius-xl) - 12px);
  object-fit: cover;
  background: #050607;
  box-shadow: 0 12px 26px rgba(6, 10, 14, 0.28);
}

.hero-video-placeholder figcaption {
  margin: 0;
  font-size: 0.92rem;
  color: rgba(255, 255, 255, 0.78);
  text-align: center;
}

.pi-titles {
  display: grid;
  gap: 0.22rem;
  margin: -0.2rem 0 0.2rem;
  padding-top: 0;
  font-size: 0.88rem;
  line-height: 1.4;
  color: var(--muted);
}

.pi-titles p {
  margin: 0;
}

.spotlight-copy .lead {
  margin: 0.25rem 0 0;
  padding: 1.2rem 1.3rem;
  border-left: 4px solid var(--accent);
  border-radius: 0 var(--radius-lg) var(--radius-lg) 0;
  background:
    linear-gradient(135deg, rgba(102, 48, 56, 0.09), rgba(85, 125, 146, 0.07)),
    rgba(255, 255, 255, 0.56);
  color: var(--ink);
  font-size: 1.08rem;
  line-height: 1.7;
  box-shadow: inset 0 0 0 1px rgba(255, 255, 255, 0.45);
}

.hero-actions {
  display: flex;
  gap: 0.9rem;
  flex-wrap: wrap;
  margin: 1.45rem 0 0.4rem;
}

.button {
  display: inline-flex;
  align-items: center;
  justify-content: center;
  min-height: 3rem;
  padding: 0.92rem 1.35rem;
  border-radius: var(--radius-md);
  font-weight: 700;
}

.button-primary {
  background: var(--accent);
  color: white;
}

.button-primary:hover,
.button-primary:focus-visible {
  background: #4a1f27;
}

.button-secondary {
  background: rgba(102, 48, 56, 0.1);
  color: var(--accent);
}

.plain-list {
  margin: 0;
  padding: 0;
  list-style: none;
}

.plain-list li {
  padding: 0.95rem 1rem;
  border-radius: var(--radius-md);
  background: rgba(255, 255, 255, 0.62);
  border: 1px solid var(--line);
  border-left: 3px solid rgba(102, 48, 56, 0.22);
}

.hero-panel {
  padding: 2rem;
  display: flex;
  flex-direction: column;
  justify-content: center;
  background:
    linear-gradient(180deg, rgba(102, 48, 56, 0.95), rgba(74, 31, 39, 0.9)),
    radial-gradient(circle at top right, rgba(182, 147, 82, 0.16), transparent 26%),
    linear-gradient(135deg, rgba(255, 255, 255, 0.06), transparent 50%);
  color: white;
}

.hero-panel .panel-kicker,
.hero-panel p,
.hero-panel span {
  color: rgba(255, 255, 255, 0.8);
}

.section {
  padding: 1.15rem 0 0.8rem;
}

.section-heading {
  display: grid;
  gap: 0.6rem;
  margin-bottom: 1rem;
}

.cards {
  display: grid;
  gap: 1.2rem;
}

.two-up {
  grid-template-columns: repeat(2, minmax(0, 1fr));
}

.research-grid {
  align-items: stretch;
}

.research-grid > .topic-card:last-child {
  grid-column: 1 / -1;
  justify-self: center;
  width: min(100%, calc(50% - 0.6rem));
}

.card,
.finding-card,
.people-column {
  padding: 1.35rem;
}

.future-section .card:nth-child(1) {
  background:
    linear-gradient(180deg, rgba(252, 248, 248, 0.9), rgba(255, 255, 255, 0.72)),
    var(--surface);
}

.figure-band .card:nth-child(1),
.people-column:first-child {
  background:
    linear-gradient(180deg, rgba(247, 250, 252, 0.9), rgba(255, 255, 255, 0.72)),
    var(--surface);
}

.future-section .card:nth-child(2),
.people-column:last-child {
  background:
    linear-gradient(180deg, rgba(252, 249, 246, 0.9), rgba(255, 255, 255, 0.72)),
    var(--surface);
}

.future-card {
  padding: 1.55rem;
}

.future-card h3 {
  margin-bottom: 0.85rem;
}

.future-card .plain-list {
  display: grid;
  gap: 0.7rem;
}

.future-card .plain-list li {
  line-height: 1.55;
}

.spotlight-grid {
  display: grid;
  grid-template-columns: 0.72fr 1.28fr;
  gap: 1.3rem;
  align-items: stretch;
}

.portrait-card {
  padding: 1.05rem;
}

.portrait-photo {
  width: 100%;
  min-height: 18.5rem;
  border-radius: calc(var(--radius-xl) - 6px);
  object-fit: contain;
  object-position: center top;
  border: 1px solid rgba(255, 255, 255, 0.7);
  box-shadow: inset 0 0 0 1px rgba(255, 255, 255, 0.28);
  background: rgba(255, 255, 255, 0.9);
}

.portrait-placeholder {
  display: grid;
  place-items: center;
  background:
    radial-gradient(circle at 50% 34%, rgba(255, 255, 255, 0.9) 0 12%, transparent 13%),
    radial-gradient(ellipse at 50% 74%, rgba(255, 255, 255, 0.78) 0 22%, transparent 23%),
    linear-gradient(145deg, rgba(102, 48, 56, 0.9), rgba(85, 125, 146, 0.72));
  border-radius: calc(var(--radius-xl) - 6px);
  min-height: 18.5rem;
  color: var(--accent);
  font-weight: 700;
  text-align: center;
  border: 1px solid rgba(255, 255, 255, 0.7);
}

.portrait-initials {
  display: grid;
  place-items: center;
  width: 5.4rem;
  height: 5.4rem;
  border-radius: 50%;
  background: rgba(255, 255, 255, 0.9);
  color: var(--accent);
  font-family: "Source Serif 4", serif;
  font-size: 1.65rem;
  letter-spacing: 0.04em;
  box-shadow: 0 10px 24px rgba(16, 33, 44, 0.12);
}

.portrait-caption {
  padding: 1rem 0 0.35rem;
}

.spotlight-copy {
  display: grid;
  align-content: start;
  gap: 1.1rem;
}

.topic-card {
  position: relative;
  overflow: hidden;
}

.topic-link {
  color: var(--ink);
  text-decoration: none;
  display: inline-flex;
  align-items: center;
  gap: 0.45rem;
}

.topic-link::after {
  content: "View papers";
  font-family: "Manrope", sans-serif;
  font-size: 0.72rem;
  font-weight: 700;
  letter-spacing: 0.06em;
  text-transform: uppercase;
  color: var(--accent);
}

.topic-link:hover,
.topic-link:focus-visible {
  color: var(--accent);
}

.topic-card::after {
  content: "";
  position: absolute;
  width: 8rem;
  height: 8rem;
  right: -2rem;
  bottom: -2rem;
  border-radius: 18px;
  background: radial-gradient(circle, rgba(102, 48, 56, 0.12), transparent 70%);
}

.finding-card:nth-child(odd)::before {
  content: "";
  display: block;
  width: 3.2rem;
  height: 0.22rem;
  border-radius: var(--radius-md);
  background: linear-gradient(90deg, var(--accent), rgba(182, 147, 82, 0.75));
  margin-bottom: 0.55rem;
}

.finding-card:nth-child(even)::before {
  content: "";
  display: block;
  width: 3.2rem;
  height: 0.22rem;
  border-radius: var(--radius-md);
  background: linear-gradient(90deg, var(--accent-blue), rgba(102, 48, 56, 0.75));
  margin-bottom: 0.55rem;
}

.findings-groups {
  display: grid;
  gap: 1.15rem;
}

.findings-group {
  display: grid;
  gap: 0.7rem;
  scroll-margin-top: 7rem;
}

.findings-group-heading {
  display: grid;
  gap: 0.28rem;
}

.findings-group-heading h3,
.findings-group-heading p {
  margin: 0;
}

.findings-group-heading h3 {
  font-size: 1.35rem;
}

.findings-list {
  display: grid;
  gap: 0.7rem;
}

.inline-figure {
  display: grid;
  place-items: center;
  min-height: 12.5rem;
  margin-bottom: 1rem;
  padding: 0.55rem;
  border-radius: calc(var(--radius-xl) - 8px);
  background: rgba(255, 255, 255, 0.9);
  border: 1px solid rgba(16, 33, 44, 0.08);
  overflow: hidden;
}

.figure-zoom {
  display: grid;
  place-items: center;
  width: 100%;
  height: 100%;
  padding: 0;
  border: 0;
  background: transparent;
  cursor: zoom-in;
}

.figure-placeholder {
  display: grid;
  place-items: center;
  width: 100%;
  height: 100%;
  min-height: inherit;
  padding: 1rem;
  text-align: center;
  color: var(--muted);
  font-size: 0.95rem;
  border: 1px dashed rgba(16, 33, 44, 0.18);
  border-radius: calc(var(--radius-xl) - 12px);
  background: linear-gradient(180deg, rgba(255, 255, 255, 0.66), rgba(244, 238, 239, 0.82));
}

.inline-figure-caption {
  margin: -0.25rem 0 0.9rem;
  text-align: center;
  font-size: 0.9rem;
  color: var(--muted);
}

.figure-zoom:focus-visible {
  outline: 3px solid rgba(102, 48, 56, 0.35);
  outline-offset: 3px;
}

.inline-figure img,
.figure-zoom img {
  width: 100%;
  height: 100%;
  object-fit: contain;
}

.wide-figure {
  min-height: 16rem;
}

.gene-figure {
  min-height: 7.5rem;
}

.infection-figure {
  min-height: 16rem;
}

.finding-card {
  display: grid;
  grid-template-columns: 1fr;
  gap: 0.45rem;
  align-items: start;
  padding: 1.05rem 1.15rem;
}

.finding-card > div {
  display: grid;
  grid-template-columns: 1fr auto;
  gap: 0.25rem 0.8rem;
  align-items: start;
}

.finding-card h3 {
  grid-column: 1 / 2;
  font-size: 1.2rem;
  line-height: 1.12;
}

.finding-card p,
.finding-label {
  margin: 0;
}

.finding-label {
  grid-column: 1 / 2;
}

.pubmed-button {
  grid-column: 2 / 3;
  grid-row: 1 / 3;
  align-self: start;
  padding: 0.4rem 0.65rem;
  border: 1px solid rgba(102, 48, 56, 0.22);
  border-radius: var(--radius-md);
  background: rgba(102, 48, 56, 0.08);
  color: var(--accent);
  font-size: 0.76rem;
  font-weight: 700;
  letter-spacing: 0.04em;
  text-transform: uppercase;
}

.pubmed-button:hover,
.pubmed-button:focus-visible {
  background: var(--accent);
  color: white;
}

.people-grid {
  display: grid;
  grid-template-columns: minmax(0, 0.88fr) minmax(0, 1.12fr);
  gap: 1.2rem;
  align-items: start;
}

.member-list,
.alumni-list {
  display: grid;
  gap: 0.65rem;
  margin-top: 0.8rem;
}

.alumni-list {
  grid-template-columns: repeat(2, minmax(0, 1fr));
  grid-auto-flow: row;
  align-items: start;
}

.member-card,
.alumni-card {
  padding: 0.85rem 1rem;
  border-radius: var(--radius-md);
  background: linear-gradient(180deg, rgba(255, 255, 255, 0.84), rgba(251, 248, 248, 0.72));
  border: 1px solid var(--line);
}

.alumni-card {
  min-height: 3.2rem;
  display: flex;
  align-items: center;
}

.people-column:first-child {
  padding: 1.15rem 1.05rem 0.95rem;
}

.people-column:first-child .member-list {
  gap: 0.55rem;
  margin-top: 0.65rem;
}

.people-column:first-child .member-card {
  padding: 0.72rem 0.82rem;
}

.member-card {
  display: grid;
  grid-template-columns: 4.2rem 1fr;
  gap: 0.8rem;
  align-items: center;
}

.person-photo,
.person-placeholder {
  display: grid;
  place-items: center;
  width: 4.2rem;
  min-height: 4.2rem;
  border-radius: var(--radius-md);
}

.person-photo {
  object-fit: cover;
  border: 1px solid rgba(16, 33, 44, 0.08);
  background: rgba(255, 255, 255, 0.9);
}

.person-placeholder {
  background:
    radial-gradient(circle at 50% 32%, rgba(255, 255, 255, 0.9) 0 16%, transparent 17%),
    radial-gradient(ellipse at 50% 78%, rgba(255, 255, 255, 0.72) 0 28%, transparent 29%),
    linear-gradient(145deg, rgba(102, 48, 56, 0.78), rgba(85, 125, 146, 0.64));
  border: 1px solid rgba(16, 33, 44, 0.08);
  color: var(--accent);
  font-size: 0.72rem;
  font-weight: 700;
}

.member-card h4,
.alumni-card h4 {
  margin: 0;
  width: 100%;
}

.alumni-name-with-link {
  display: flex;
  align-items: center;
  justify-content: space-between;
  gap: 0.75rem;
  color: var(--ink);
  width: 100%;
}

.alumni-name-with-link span {
  color: var(--ink);
  min-width: 0;
}

.alumni-link-icon {
  display: inline-flex;
  align-items: center;
  justify-content: center;
  width: 1rem;
  height: 1rem;
  flex: 0 0 auto;
}

.alumni-link-icon img {
  width: 100%;
  height: 100%;
  object-fit: contain;
}

.member-card p,
.alumni-card p {
  margin: 0.12rem 0 0;
  line-height: 1.35;
}

.member-card span,
.alumni-card span {
  display: block;
  margin-top: 0.12rem;
  line-height: 1.45;
}

.is-hidden {
  display: none;
}

.institutional-line {
  width: min(calc(100% - 2rem), var(--max-width));
  margin: 1.5rem auto 2.5rem;
  color: var(--muted);
  font-size: 0.86rem;
  line-height: 1.72;
  text-align: center;
}

.site-credit {
  width: min(calc(100% - 2rem), var(--max-width));
  margin: -1.8rem auto 2.5rem;
  color: var(--muted);
  font-size: 0.78rem;
  line-height: 1.5;
  text-align: center;
}

.image-modal {
  position: fixed;
  inset: 0;
  z-index: 100;
  display: none;
  place-items: center;
  padding: 5rem 2rem 2rem;
  background: rgba(12, 25, 33, 0.82);
}

.image-modal.is-open {
  display: grid;
}

.image-modal img {
  max-width: min(99vw, 1560px);
  max-height: 95vh;
  object-fit: contain;
  background: white;
  border-radius: var(--radius-lg);
  box-shadow: 0 24px 70px rgba(0, 0, 0, 0.35);
}

.modal-close {
  position: fixed;
  top: 1rem;
  right: 1rem;
  border: 0;
  border-radius: var(--radius-md);
  padding: 0.7rem 0.9rem;
  background: rgba(255, 255, 255, 0.94);
  color: var(--ink);
  font: inherit;
  font-weight: 700;
  cursor: pointer;
}

@keyframes fade-up {
  from {
    opacity: 0;
    transform: translateY(18px);
  }

  to {
    opacity: 1;
    transform: translateY(0);
  }
}

@media (max-width: 980px) {
  .hero-grid,
  .spotlight-grid,
  .two-up,
  .people-grid,
  .finding-card {
    grid-template-columns: 1fr;
  }

  .research-grid > .topic-card:last-child {
    grid-column: auto;
    justify-self: stretch;
    width: 100%;
  }

  .alumni-list {
    grid-template-columns: 1fr;
  }

}

@media (max-width: 760px) {
  .topbar {
    border-radius: var(--radius-lg);
    align-items: flex-start;
    flex-wrap: wrap;
  }

  .menu-toggle {
    display: inline-flex;
  }

  .nav-links {
    display: none;
    flex-direction: column;
    align-items: flex-start;
    width: 100%;
    padding-top: 0.5rem;
  }

  .nav-links.is-open {
    display: flex;
  }

  .hero-copy,
  .hero-panel,
  .card,
  .people-column,
  .finding-card {
    padding: 1.2rem;
  }

  .hero-grid {
    padding-top: 1.8rem;
  }

}